中国药物警戒 ›› 2010, Vol. 7 ›› Issue (4): 246-248.

• 药品不良反应监测 • 上一篇    下一篇

46例注射用头孢哌酮/舒巴坦致过敏性休克分析

田艳平1, 朱燕1, 尹红1, 关颖卓1, 赵志刚2, 崔向丽2*   

  1. 1北京航天总医院药剂科,北京 100076;
    2首都医科大学北京天坛医院药剂科,北京 100050
  • 收稿日期:2009-11-17 修回日期:2016-02-19 出版日期:2010-04-08 发布日期:2016-02-19
  • 通讯作者: 崔向丽,女,博士,临床药学。E-mail:Cui10@163.com
  • 作者简介:田艳平,女,本科,临床药学。

Analysis of 46 Cases of Allergic Shock Induced by Cefoperazone /Sulbactam

TIAN Yan-ping1, ZHU Yan1, YIN Hong1, GUAN Ying-zhuo1, ZHAO Zhi-gang2, CUI Xiang-li2,*   

  1. 1Department of Pharmacy, Beijing Aerospace Hospital, Beijing 100076, China;
    2Department of Pharmacy, Beijing Tiantan Hospital, Beijing 100050 China
  • Received:2009-11-17 Revised:2016-02-19 Online:2010-04-08 Published:2016-02-19

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摘要： 目的 分析注射用头孢哌酮/舒巴坦致过敏性休克的情况,为临床合理用药提供参考。方法 对国内、外2003年1月~2009年6月公开发表的注射用头孢哌酮/舒巴坦出现的46例过敏性休克的不良反应报道进行整理、归纳和分析。结果 46例发生过敏性休克的患者中,老年患者出现比例较高;有42例患者在输注头孢哌酮/舒巴坦30分钟内发生过敏性休克;9例患者发生休克后抢救无效死亡。结论 临床应加强对注射用头孢哌酮/舒巴坦不良反应的预防和监测,避免发生过敏性休克等严重不良反应。

关键词: 注射用头孢哌酮/舒巴坦, 过敏性休克, 不良反应

Abstract: Objective To summarize allergic shock of cefoperazone/sulbactam for injection, prove information for rational use of it in clinic. Methods 46 cases of allergic Shock caused by cefoperazone/sulbactam for injection ranging from January 2003 to June 2009 were collected by statistically classified and analyzed. Results Elderly patients occurred allergic shock with a higher proportion during the 46 cases;there were 42 patients who Started anaphylactic shock in 30 minutes after the infusion started,then they received emergency resuscitation, but 9 patients died at last. Conclusion Attention should be paid to adverse drug reaction(ADR) of cefoperazone/sulbactam for injection.

Key words: cefoperazone/sulbactam for injection, allergic Shock, adverse drug reaction(ADR)

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