中国药物警戒 ›› 2010, Vol. 7 ›› Issue (1): 4-6.

• 基础研究 • 上一篇    下一篇

当归贝母苦参丸对小鼠良性前列腺增生的抑制作用研究

陈野1, 赵东2, 蔡淼3, 温得中1, 孙健2*   

  1. 1吉林大学白求恩医学院 吉林 长春 130021;
    2中国中医科学院医学实验中心,北京 100700;
    3吉林省妇幼保健院,吉林 长春 130061
  • 收稿日期:2016-02-18 修回日期:2016-02-18 出版日期:2010-01-08 发布日期:2016-02-18
  • 通讯作者: *通讯作者：孙健,男,博士,药物化学分析。E-mail:sunjiankw@163.com
  • 作者简介:陈野,男,在读博士研究生,病理学与病理生理学。
  • 基金资助:
    中国中医科学院基本科研业务项目（ZZ2007012）

Antagonistic Effect of Dangguibeimukushen Pill on Prostatic Hyperplasia in Mice

CHEN Ye1, ZHAO Dong2, CAI Miao3, WEN De-zhong1, SUN Jian2,*   

  1. 1Norman Bethune College of Medicine Jilin University, Jilin Changchun 130021, China;
    2Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700,China;
    3Jilin Maternal and Child Care Service Centre, Jilin Changchun 130061, China
  • Received:2016-02-18 Revised:2016-02-18 Online:2010-01-08 Published:2016-02-18

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摘要： 目的 通过研究当归贝母苦参丸（DBK）对小鼠前列腺增生（BPH）及性激素平衡的影响,为临床用药提供药理学研究依据。方法 采用皮下注射丙酸睾酮制作去势小鼠前列腺增生模型,观察各组前列腺指数、性激素水平及腺细胞病理改变。结果 DBK治疗14 d后,与模型组相比,DBK组小鼠前列腺湿重及前列腺指数出现剂量依赖性降低（P<0.05或P<0.01）,明显改善前列腺组织病理结构;血清丙酸睾酮（T）、雌二醇（E2）含量明显降低（P<0.05或P<0.01）。结论 DBK对丙酸睾酮所致小鼠BPH具有显著的拮抗作用,其作用机制在一定程度上与降低小鼠血清T、E2含量有关。

关键词: 当归贝母苦参丸, 良性前列腺增生, 小鼠

Abstract: Objective To study the antagonistic effect of Dangguibeimukushen Decoction（DBK） on benign prostatic hyperplasia（BPH） and its possiblemechanism. Methods Experimental prostatic hyperplasia was produced in the mice by testosterone injection.After 14 days of the treatments, the mice were sacrificed for measure-ment of the prostate glandular wet weight, the index of prostate gland（PI）, the pathologic changes of prostate gland by light microscopy and the contents of testosterone and estradiol in the serum. Results The prostate wet weight and PI decreased dose dependently after DBK treatment for 14 days compared with the BPH model group（P <0.05or P <0.01）. DBK reduced the serum testosterone, estradiol contents （P <0.05or P <0.01）. Conclusion DBK has significant antagonistic effect on BPH induced by testosterone propionate in mice, which may involve its regulatory action on the sex hormone balance.

Key words: Dangguibeimukushen pill, benign prostatic hyperplasia, mice

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