7种常见易发生不良反应真菌的毒性分析及安全应用

doi:10.19803/j.1672-8629.20240143

中国药物警戒 ›› 2024, Vol. 21 ›› Issue (5): 489-495.
DOI: 10.19803/j.1672-8629.20240143

• 药用真菌资源开发与安全应用专栏（一） • 上一篇下一篇

7种常见易发生不良反应真菌的毒性分析及安全应用

刘天睿^1,2,3, 李瑶^1,2, 陈瑜鑫^1,2, 李慧^1,2, 高海云^1,2, 袁媛^1,2,4,*

¹中国中医科学院中医药健康产业研究所,中药资源可持续利用江西省重点实验室,江西南昌 330115;
²江西中医药健康产业研究院,江西南昌 330115;
³昭通学院,云南省天麻与真菌共生生物学重点实验室,云南昭通 657099;
⁴中国中医科学院中药资源中心,道地药材品质保障与资源持续利用全国重点实验室,北京 100700

收稿日期:2024-02-29 出版日期:2024-05-15 发布日期:2024-05-13
通讯作者: ^*袁媛,女,博士,研究员·博导,中药鉴定与分子生药学。E-mail：y_yuan0732@163.com
作者简介:刘天睿,男,博士,助理研究员,药用真菌资源开发利用。
基金资助:
中央级公益性科研院所基本科研业务费专项（ZZ16-ND-12、ZZ16-XRZ-105）; 中国中医科学院科技创新工程重大攻关项目（CI2021B014、CI2023D001/CI2023E002-04）; 中央本级重大增减支项目（2060302）; 江西省“双千计划”项目; 云南省天麻与真菌共生生物学重点实验室开放课题项目（TMKF2023B01）; 国家杰出青年科学基金（82325049）

Toxicity analysis and safe application of 7 common fungi prone to adverse reactions

LIU Tianrui^1,2,3, LI Yao^1,2, CHEN Yuxin^1,2, LI Hui^1,2, GAO Haiyun^1,2, YUAN Yuan^1,2,3,*

¹Key Laboratory of Sustainable Utilization of Traditional Chinese Medicine Resources in Jiangxi Province, Institute of Traditional Chinese Medicine Health Industry, China Academy of Chinese Medical Sciences, Nanchang Jiangxi 330115, China;
²Jiangxi Health Industry Institute of Traditional Chinese Medicine, Nanchang Jiangxi 330115, China;
³Yunnan Key Laboratory of Gastrodia and Fungi Symbiotic Biology, Zhaotong University, Zhaotong Yunnan 657099, China;
⁴State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica China Academy of Chinese Medical Sciences, Beijing 100700, China

Received:2024-02-29 Online:2024-05-15 Published:2024-05-13

摘要/Abstract

摘要： 目的综述见手青类、胶陀螺、黑木耳、鹅膏菌类、橘黄裸伞、毛头鬼伞、卷边桩菇7种常见易发生不良反应条件性真菌研究现状,对其毒性成分进行分析,提出相应的安全应用建议,为资源开发及可持续应用提供参考。方法通过查阅国内外文献及相关书籍,对7种常见易发生不良反应真菌的研究现状、功效作用、毒性成分、不良反应等进行总结。结果 7种常见易发生不良反应真菌所含的毒性成分种类复杂,包括多肽、生物碱、氨基酸、低聚异戊二烯类等化合物,可能会引起神经毒性、光敏毒性、胃肠道刺激、双硫仑样反应、溶血性中毒等不良反应,需引起重视。同时,这些真菌富含多种生物活性成分,具有显著药理活性,部分毒性成分又具开发成抗炎、镇痛、抗抑郁等药的潜力,值得更深入研究及合理开发应用。结论易发生不良反应真菌亦是重要的药用真菌资源,极具开发价值,目前许多易发生不良反应真菌研究重点多偏重药理作用和毒理作用,其毒力因子及其中毒机制尚未明确,需进一步深入研究,为其开发应用提供参考。

关键词: 条件性真菌, 神经毒性, 光敏毒性, 胃肠道刺激, 双硫仑样反应, 不良反应, 毒性成分, 安全应用

Abstract: Objective To review of research status on seven common conditional fungi that are prone to adverse reactions, analyze their toxic components, and propose corresponding safety utilization suggestions, so as to provide reference for their resource development and sustainable utilization. Methods By reviewing domestic and foreign literature and relevant books, the current research status, efficacy, toxic components, adverse reactions, and other aspects of seven common fungi that are prone to adverse reactions were summarized. Results Seven types of common fungi that are prone to adverse reactions, including Boletus、Bulgaria inguinans、Auricularia auricula、Amanita、Gymnopilus spectabilis、Coprinus comatus、Paxillus involutus contain complex types of toxic components, including peptides, alkaloids, amino acids, oligoisoprene compounds, etc, which may cause adverse reactions such as neurotoxicity, photosensitivity, gastrointestinal irritation, disulfiram-like reaction, hemolytic poisoning, etc. It is important to pay attention to them.. At the same time, these fungi are rich in various bioactive components with significant pharmacological activity, and some toxic components have the potential to be developed into anti-inflammatory, analgesic, antidepressant drugs, etc, which is worthy of further research and rational utilization. Conclusion Fungi that are prone to adverse reactions are also important resources for medicinal fungi, with great development value. Currently, many studies on fungi that are prone to adverse reactions focus on pharmacological and toxicological effects. Their virulence factors and toxic mechanisms are not yet clear, and further in-depth research is needed to provide theoretical basis for their development and utilization.

Key words: conditional fungi, neurotoxicity, photosensitivity, gastrointestinal irritation, disulfiram-like reaction, adverse reactions, toxic components, secure applications

中图分类号:

RR917
R994.1

刘天睿, 李瑶, 陈瑜鑫, 李慧, 高海云, 袁媛. 7种常见易发生不良反应真菌的毒性分析及安全应用[J]. 中国药物警戒, 2024, 21(5): 489-495.

LIU Tianrui, LI Yao, CHEN Yuxin, LI Hui, GAO Haiyun, YUAN Yuan. Toxicity analysis and safe application of 7 common fungi prone to adverse reactions[J]. Chinese Journal of Pharmacovigilance, 2024, 21(5): 489-495.

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参考文献

[1] LIU R.Preliminary investigation and exploration of development and utilization of large fungal resources in Xinglongshan national nature reserve, Gansu province[J]. Contemporary Horticulture(现代园艺), 2024, 47(2): 15-17, 28.
[2] YANG ZL, WU G, LI YC, et al.Common Edible and Poisonous Mushrooms of Southwestern China(中国西南地区常见食用菌和毒菌)[M]. Beijing: Science Press, 2021.
[3] DAI YC.New trends in the research and development of edible and medicinal fungi in China: analysis of papers published in Chinese Journal of Fungi from 2000 to 2021[J]. Microbiol Research(菌物研究), 2022, 20(2): 141-156.
[4] LI HJ, ZHANG YZ, LIU ZT, et al.Species diversity of poisonous mushrooms in mushroom poisoning events in Yunnan province[J]. Mycosystema(菌物学报), 2022, 41(9): 1416-1429.
[5] YANG ZL, WU G, LI YC.Mushrooms of Yunnan(云南野生菌)[M]. Beijing: Science Press, 2022.
[6] WU Y, DU JX, ZHANG J, et al.Analysis of bacterial diversity in shiroes soil of Boletus magnificus by high-throughput sequencing[J]. Edible Fungi of China(中国食用菌), 2021, 40(1): 84-90.
[7] ZHANG Y.Principle of inhibition of motor nervous system by alkaloids of Boletus parviflora[J]. Edible Fungi of China(中国食用菌), 2020, 39(3): 41-43.
[8] WU F, ZHOU LW, YANG ZL, et al.Resource diversity of Chinese macrofungi: edible, medicinal and poisonous species[J]. Fungal Diversity, 2019, 98(1): 1-76.
[9] LI JP, ZHONG JJ, YAO QM, et al.Clinical characteristics analysis of 36 cases of hallucinogenic boletus poisoning[J]. Chinese Journal of Nervous and Mental Diseases(中国神经精神疾病杂志), 2023, 49(10): 577-583.
[10] LI Y, LI HJ, FU YS, et al.Analysis of epidemiology and clinical characteristics of Lanmaoa asiatica poisoning[J]. Journal of Clinical Emergency(临床急诊杂志), 2023, 24(5): 258-261, 265.
[11] DAI RX, MENG Q, CHEN GB.Research progress of neuropsychiatric poisonous mushrooms and their toxins[J]. Chinese Journal of Nervous and Mental Diseases(中国神经精神疾病杂志), 2022, 48(8): 493-497.
[12] SONG SF.Patients were admitted to ICU after eating red onion online shopping[J]. China Food Industry(中国食品工业), 2022(13): 82-83.
[13] SANG HZ, XIE Y, SU X, et al.Mushroom Bulgaria inquinans modulates host immunological response and gut microbiota in mice[J]. Frontiers in Nutrition, 2020, 7: 144.
[14] SHEN SJ, FENG ZY, JIANG SJ, et al.Azaphilones from the fungus Penicillium multicolor LZUC-S2 and their antibacterial activity[J]. Chemistry & Biodiversity, 2023, 20(3): e202201180.
[15] HAN H.Antimalarial activity of Ginseng polysaccharides and Bulgaria Inauinans polysaccharides[D]. Changchun: Northeast Normal University(东北师范大学), 2008.
[16] BI H, HAN H, LI Z, et al.A water-soluble polysaccharide from the fruit bodies of Bulgaria inquinans (fries) and its anti-malarial activity[J]. Evidence-Based Complementary and Alternative Medicine, 2011, 2011: 973460.
[17] SANG HZ.Effects of Bulgaria Inquinans on murine immune functions and gut microbiota[D]. Zhengzhou: Henan University, 2021.
[18] JIANG S, TSUMURO T, TAKUBO M, et al.Antipruritic and antierythema effects of ascomycete Bulgaria inquinans extract in ICR mice[J]. Biological & Pharmaceutical Bulletin, 2005, 28(12): 2197-2200.
[19] JIAO LH, WANG FL, MA YP, et al.Research progress on molecular biology of Auricularia heimuer[J]. Northern Horticulture(北方园艺), 2023(17): 124-129.
[20] ZHANG ZX.Research progress on action and application of main biological activities of Auricularia auricular[J]. Edible and Medicinal Mushrooms(食药用菌), 2022, 30(1): 20-25.
[21] ZHANG HY, ZHAO SJ, LI H, et al.Bioactive substances of Auricularia auricularia and its processing status in food industry[J]. Modern Agricultural Science and Technology(现代农业科技), 2023(1): 173-180.
[22] YANG GL. What are the hazards of soaking Auricularia auricula for a long time[N]. China Science Daily, 2015-07-15(8).
[23] LI ZJ, BAO HY.Correlation between different soaking way and content of diisobutyl phthalate in Auricularia heimuer[J]. Mycosystema(菌物学报), 2018, 37(3): 389-394.
[24] SEUNG HJ, JI HJ, HEA YC, et al.Toxicokinetic studies of di-isobutyl phthalate focusing on the exploration of gender differences in rats[J]. Chemosphere, 2022, 286(P1): 131706.
[25] KIM SM, KIM YH, HAN GU, et al.Diisobutyl phthalate (DiBP)-induced male germ cell toxicity and its alleviation approach[J]. Food and Chemical Toxicology, 2024, 184: 114387.
[26] PEI CX, LI Z, ZHANG YM, et al.Effect of PAEs on IL-4 production in primary lymphocyte[J]. Journal of Shenyang Medical College(沈阳医学院学报), 2009, 11(2): 77-78, 90.
[27] ZHU C, SUN Y, ZHAO Y, et al.Associations between Children's asthma and allergic symptoms and phthalates in dust in metropolitan Tianjin, China[J]. Chemosphere, 2022, 302: 134786.
[28] DENG WQ, XIAO ZR, LI P, et al.Purification of toxins from Amanita exitialis and their anti-tumor effects in vitro[J]. Acta Edulis Fungi(食用菌学报), 2012, 19(4): 71-78.
[29] TIZIANA V, NICOLETTA V, MATILDE M, et al.Anti-CD37 alpha-amanitin conjugated antibodies as potential therapeutic weapons for Richter's syndrome[J]. Blood, 2022, 140(13):1565-1569.
[30] CHU JZ, CUI Q, YANG SD, et al.Research progress on toxicity mechanism of mushroom toxins[J]. Chinese Traditional and Herbal Drugs(中草药), 2022, 53(24): 7925-7932.
[31] ZAVADINACK M, DE LBD, DA RBJL, et al.An α-D-galactan and a β-D-glucan from the mushroom Amanita muscaria: structural characterization and antitumor activity against melanoma[J]. Carbohydrate Polymers, 2021, 274(15): 118647.
[32] KONDEVA B, VOYNOVA M, SHKONDROV A, et al.Effects of Amanita muscaria extract on different in vitro neurotoxicity models at sub-cellular and cellular levels[J]. Food and Chemical Toxicology, 2019, 132: 110687.
[33] LI YH, HSU DZ, LIU CT, et al.The protective effect of muscimol against systemic inflammatory response in endotoxemic mice is independent of GABAergic and cholinergic receptors[J]. Canadian Journal of Physiology and Pharmacology, 2022, 100(7): 665-678.
[34] JOHNSTON GA.Muscimol as an ionotropic GABA receptor agonist[J]. Neurochemical Research, 2014, 39(10): 1942-1947.
[35] STEBELSKA K.Fungal hallucinogens psilocin, ibotenic acid, and muscimol: analytical methods and biologic activities[J]. Therapeutic Drug Monitoring, 2013, 35(4): 420-442.
[36] VOYNOVA M, SHKONDROV A, BURDINA KM, et al.Toxicological and pharmacological profile of Amanita muscaria (L.) Lam.-a new rising opportunity for biomedicine[J]. Pharmacia, 2020, 67(4): 317-323.
[37] QUENTIN C, MICHEL L.Amanita muscaria: ecology, chemistry, myths[J]. Encyclopedia, 2021, 1(3): 905-914.
[38] MICHELOT D, MELENDEZ-HOWELL LM.Amanita muscaria: chemistry, biology, toxicology, and ethnomycology[J]. Mycological Research, 2003, 107(Pt2): 131-146.
[39] HU YP, ZHANG JX, ZHAO LQ, et al.Physicochemical property and antioxidant activity of polysaccharide from Gymnopilus spectabilis[J]. Natural Product Research and Development(天然产物研究与开发), 2018, 30(2): 274-279.
[40] HU YP, LIN LH, LI N, et al. Study on antioxidation and anti diabetes mechanism of polysaccharides from several edible and medicinal fungi[EB/OL]. (2021-11-16)[2024-04-14]. https://kns-cnki-net-443.webvpn.wzu.edu.cn/kcms2/article/abstract?v=6zqdfgkTh_rWPOVFx9SQoojQiBvHLCA6AoWbLna0egJziFc1R0m79HU5gY5AdnKrNNlVfQd52QjIEVZmREf2nePAKjHyD-M7i7yQrm_9D1KzF09hq8ywyNHHpakRhEUw5UlQQZgWXKagpZMoCOQz2A==uniplatform=NZKPTlanguage=CHS.
[41] CHEN JB.Study on biological characteristics,chemical compositions and anti-tumor effect of Gymnopilus spectabilis[D]. Changchun: Jilin Agricultural University(吉林农业大学), 2008.
[42] BAO HY, LI Y.Studies on inhibition of the extract from Gymnopilus spectabilis to MCF-7[J]. Journal of Jilin Agricultural University(吉林农业大学学报), 2002(2): 56-58.
[43] TANAKA M, HASHIMOTO K, OKUNO T, et al.Neurotoxic oligoisoprenoids of the hallucinogenic mushroom, Gymnopilus spectabilis[J]. Phytochemistry, 1993, 34(3): 661-664.
[44] XUE RX, LIU GP, QIU BF, et al.Determination of 5 neuropsychiatric mushroom toxins in wild fungi by ultra high performance liquid chromatography-tandem mass spectrometry[J]. Chinese Journal of Industrial Medicine(中国工业医学杂志), 2024, 37(1): 96-99.
[45] AOYAGI F, MAENO S, OKUNO T, et al.Gymnopilins, bitter principles of the big-laughter mushroom Gymnopilus spectabilis[J].Tetrahedron Letters, 1983, 24(19): 1991-1994.
[46] SHUNSUKE M, NAOKI K, AIKO N, et al.Gymnopilin-a substance produced by the hallucinogenic mushroom, Gymnopilus junonius-mobilizes intracellular Ca²⁺ in dorsal root ganglion cells[J]. Biomedical Research, 2012, 33(2): 111-118.
[47] KAYANO T, KITAMURA N, MIYAZAKI S, et al.Gymnopilins, a product of a hallucinogenic mushroom, inhibit the nicotinic acetylcholine receptor[J]. Toxicon, 2014, 81: 23-31.
[48] NISHIO A, KITAMURA N, TANAKA S, et al.Multiple effects of gymnopilin on circulatory system of the rat[J]. Biological & Pharmaceutical Bulletin, 2012, 35(8): 1300-1305.
[49] YANG L, XIANG P, DANG YH, et al.Advances in analytical methods of psilocin and psilocybin[J]. Chinese Journal of Forensic Science(中国司法鉴定), 2021(2): 24-32.
[50] SHARMA P, NGUYEN QA, MATTHEWS SJ, et al.Psilocybin history, action and reaction: a narrative clinical review[J]. Journal of Psychopharmacology, 2023, 37(9): 849-865.
[51] GABLE RS.Comparison of acute lethal toxicity of commonly abused psychoactive substances[J]. Addiction, 2004, 99(6): 686-696.
[52] WATFORD T, MASOOD N.Psilocybin, an effective treatment for major depressive disorder in adults-a systematic review[J]. Clinical Psychopharmacology and Neuroscience, 2024, 22(1): 2-12.
[53] ZHANG YP, LIN XY.A case of food poisoning caused by Gymnopilus spectabilis[J]. Hunan Medicine(湖南医学), 1989, 6(3): 187.
[54] GAO Z.Characterization and mechanism on renovating diabetic nephropathic of mycelia polysaccharides from Coprinus comatus[D]. Jinan: Shandong agricultural university, 2022.
[55] ZHENG Z, QU H, ZHOU H, et al.Changes in quality, ultrastructure, reactive oxygen species and cell wall metabolisms of postharvest Coprinus comatus stored at different temperatures[J]. Scientia Horticulturae, 2022, 298: 110989.
[56] FAJAR H, HERNAYANTI H, NURAENI E, et al.Antidiabetic effects and antioxidant properties of the saggy ink cap medicinal mushroom, Coprinus comatus (agaricomycetes), in streptozotocin-induced hyperglycemic rats[J]. International Journal of Medicinal Mushrooms, 2021, 23(10): 9-21.
[57] GU DY, TANG SS, LIU C, et al.Optimization of liquid fermentation conditions for Coprinus comatus to enhance antioxidant activity[J/OL]. Preparative Biochemistry Biotechnology, [2024-02-28].https://pubmed.ncbi.nlm.nih.gov/38147976/.
[58] PATRYK N, RENATA M, KRYSTYNA G, et al.Mushrooms as potential therapeutic agents in the treatment of cancer: evaluation of anti-glioma effects of Coprinus comatus, Cantharellus cibarius, Lycoperdon perlatum and Lactarius deliciosus extracts[J]. Biomedicine Pharmacotherapy, 2021, 133: 111090.
[59] YU JY, SUN JG, SUN M, et al.Protective mechanism of Coprinus comatus polysaccharide on acute alcoholic liver injury in mice, the metabolomics and gut microbiota investigation[J]. Food Science and Human Wellness, 2024, 13(1): 401-413.
[60] LINDBERG P, BERGMAN R, WICKBERG B, et al.Isolation and structure of coprine, a novel physiologically active cyclopropanone derivative from Coprinus atramentarius and its synthesis via 1-aminocyclopropanol[J].Journal of the Chemical Society, 1975: 946.
[61] QIN Q, BAO HY, YAN F, et al.The toxicity and renal injury mechanism of disulfiram like reaction induced by Coprinus comatus[J]. Acta Edulis Fungi(食用菌学报), 2021, 28(6): 98-108.
[62] PATRYK N, SYLWIA KN, RENATA M, et al.The two faces of Coprinus comatus-functional properties and potential hazards[J]. Phytotherapy Research, 2020, 34(11): 2932-2944.
[63] TANG L, LI SJ, YANG HJ, et al.Autolysis process of neutron body and related enzyme activity changes in mushroom cultivation[J]. Microbial Research(菌物研究), 2021, 19(3): 184-190.
[64] HAI LY, ZHI HZ, HUA BZ, et al.Proteomics reveals the mechanism underlying the autolysis of postharvest Coprinus comatus fruiting bodies[J]. Journal of Agricultural and Food Chemistry, 2022, 70(4): 1346-1357.
[65] LIU Y, SHI FL, WANG GH.Isolation and identification of natural red pigment from endophytic fungi of Paxillus involutus(Batsch Fr)[J]. Food Research and Development(食品研究与开发), 2021, 42(6): 17-21.
[66] LYU JH.Study on chemical constituents and antifungal activities of Paxillus involutus and Phallus rubrovolvatus[D]. Changchun: Jilin Agricultural University, 2022.
[67] ZHANG JX, SHUI XX, JIA LF, et al.Extraction optimization and antioxidant activities of ethanol extract of the brown roll-rim mushroom Paxillus involutus (Agaricomycetes)[J]. International Journal of Medicinal Mushrooms, 2023, 25(2): 67-75.
[68] LYU JH, YAO L, ZHANG JX, et al.Novel 2,5-diarylcyclopentenone derivatives from the wild edible mushroom Paxillus involutus and their antioxidant activities[J]. Journal of Agricultural and Food Chemistry, 2021, 69(17): 5040-5048.
[69] LYU JH, YAO L, LI D, et al.Novel hypoglycemic compounds from wild mushroom Paxillus involutus[J]. Bioorganic Chemistry, 2021, 112: 104984.
[70] CHEN ZH, YANG ZL, TU LGE, et al.Poisonous Mushrooms: Recognition and Poisoning Treatment (毒蘑菇识别与中毒防治)[M]. Beijing: Science Press, 2016.
[71] LI HJ, ZHANG YZ, ZHANG HS, et al.Mushroom poisoning outbreaks-China, 2023[J]. China CDC Weekly, 2024, 6(4): 64-68.
[72] WHITE J, WEINSTEIN AS, HARO DL, et al.Mushroom poisoning: a proposed new clinical classification[J]. Toxicon, 2019, 157: 53-65.
[73] SHEN P, SUN DZ, ZHOU W, et al.Research progress in toxicity prediction of traditional Chinese medicines[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2023, 20(4): 473-479.

7种常见易发生不良反应真菌的毒性分析及安全应用

Toxicity analysis and safe application of 7 common fungi prone to adverse reactions

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