上皮间质转化与肝纤维化之间的联系研究进展

doi:10.19803/j.1672-8629.20230536

摘要/Abstract

摘要： 肝纤维化是一个病理生理过程,指由各种致病因子所致肝内结缔组织异常增生。任何肝脏损伤在肝脏修复愈合的过程中都有肝纤维化的过程,如果损伤因素长期不能去除,纤维化的过程长期持续就会发展成肝硬化甚至是肝癌,因此逆转肝纤维化具有重要意义。近年来上皮间质转化的研究越来越多,研究发现肝纤维化中同样存在上皮间质转化,因此逆转上皮间质转化是逆转肝纤维化的机制之一,本文综述了在肝纤维化中发生上皮间质转化的细胞类型、上皮间质转化相关信号通路在肝纤维化中的作用机制以及通过上皮间质转化影响肝纤维化的非编码RNA,以期为肝纤维化的研究治疗提供理论依据。

关键词: 上皮间质转化, 肝纤维化, 肝癌, 信号转导通路, 非编码RNA, 逆转

Abstract: Hepatic fibrosis is a pathophysiological process, which refers to abnormal hyperplasia of hepatic connective tissue caused by various pathogenic factors. Any liver injury undergoes liver fibrosis in the process of liver repair and healing. As long as injury persists, fibrosis will evolve into cirrhosis or even liver cancer. Therefore, it is of great significance to reverse liver fibrosis. In recent years, increasing research has been conducted on epithelial mesenchymal transition that has been found to occur in liver fibrosis, which is why reversing epithelial mesenchymal transition is one of the mechanisms for reversing liver fibrosis. This paper reviews the cell types of epithelial mesenchymal transition in hepatic fibrosis, the mechanism of epithelial mesenchymal transition-related signaling pathways in hepatic fibrosis, and the non-coding RNAs that affects hepatic fibrosis through epithelial mesenchymal transition in order to provide data the research and treatment of hepatic fibrosis.

Key words: epithelial-mesenchymal transition, hepatic fibrosis, liver cancer, signal transduction pathway, non-coding RNA, reverse

中图分类号:

R977

李明奇, 赵晓璐, 高晓阳, 马月宏. 上皮间质转化与肝纤维化之间的联系研究进展[J]. 中国药物警戒, 2024, 21(4): 464-468.

LI Mingqi, ZHAO Xiaolu, GAO Xiaoyang, MA Yuehong. Research progress in correlations between epithelial-mesenchymal transition and hepatic fibrosis[J]. Chinese Journal of Pharmacovigilance, 2024, 21(4): 464-468.

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https://www.zgywjj.com/CN/Y2024/V21/I4/464

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