注射用培美曲塞二钠致双侧小腿罕见硬皮样皮肤1例分析

doi:10.19803/j.1672-8629.20230157

中国药物警戒 ›› 2023, Vol. 20 ›› Issue (11): 1293-1295.
DOI: 10.19803/j.1672-8629.20230157

注射用培美曲塞二钠致双侧小腿罕见硬皮样皮肤1例分析

梁艳^1,2, 闫加庆^1∆, 杨珺^1,*

¹国家癌症中心,国家肿瘤临床医学研究中心,中国医学科学院北京协和医学院肿瘤医院药剂科,北京 100021;
²北京中医药大学东直门医院药学部,北京 100700

收稿日期:2023-03-21 出版日期:2023-11-15 发布日期:2023-11-13
通讯作者: ^*杨珺,女,副主任药师,临床药学。E-mail：yangjun_99@126.com
作者简介:梁艳,女,主管药师,临床药学。^∆为并列第一作者。
基金资助:
中国癌症基金会北京希望马拉松专项基金（LC20A09）

One case of scleroderma-like skin in bilateral calves induced by pemetrexed disodium for injection

LIANG Yan^1,2, YAN Jiaqing^1∆, YANG Jun^1,*

¹Department of Pharmacy, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital of Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China;
²Department of Pharmacy, Dongzhimen Hospital Beijing University of Chinese Medicine, Beijing 100700, China

Received:2023-03-21 Online:2023-11-15 Published:2023-11-13

摘要/Abstract

摘要： 目的探讨培美曲塞罕见下肢皮肤不良反应临床特征及处理措施。方法分析1例非小细胞肺癌患者应用注射用培美曲塞二钠致小腿罕见皮肤毒性病例,结合相关文献,总结本类罕见皮肤毒性临床表现及适宜治疗方式。结果本例患者主要临床表现为肿胀、多形红斑、瘙痒、色素沉着、疼痛、硬化、发热,与国外报道的培美曲塞相关性硬皮样改变相似,应用抗菌药物治疗效果不明显,在降低培美曲塞化疗剂量,使用激素、抗组胺药物对症治疗后明显缓解。结论培美曲塞相关硬皮样改变未列入培美曲塞已知不良反应,常被误诊为蜂窝织炎或丹毒,可严重影响患者生存质量,应引起临床重视。

关键词: 注射, 培美曲塞, 下肢, 皮肤, 药品不良反应, 非小细胞肺癌

Abstract: Objective To explore the clinical characteristics and treatment of adverse reactions in the skin of lower limbs caused by pemetrexed. Methods One case of rare skin toxicity in the lower leg caused by pemetrexed disodium for injection in a patient with non-small cell lung cancer was analyzed. The clinical manifestations and appropriate treatments of such rare skin toxicity were summarized based on literature review. Results The clinical manifestations of this patient, including swelling, erythema multiforme, itching, pigmentation, pain, sclerosis, and fever, were similar to those of pemetrexed related sclerodermic changes reported abroad, and the use of antibacterial drugs had no significant effect. After the dose of pemetrexed chemotherapy was reduced and hormone and antihistamine drugs for symptomatic treatment were used, the symptoms were significantly alleviated. Conclusion The sclerodermic changes related to pemetrexed are not included in the known adverse reactions of pemetrexed and are often misdiagnosed as cellulitis or erysipelas, which can seriously affect the quality of life of patients and deserves attention.

Key words: injection, pemetrexed, lower extremity, skin, adverse drug reaction, non-small cell lung cancer

中图分类号:

梁艳, 闫加庆, 杨珺. 注射用培美曲塞二钠致双侧小腿罕见硬皮样皮肤1例分析[J]. 中国药物警戒, 2023, 20(11): 1293-1295.

LIANG Yan, YAN Jiaqing, YANG Jun. One case of scleroderma-like skin in bilateral calves induced by pemetrexed disodium for injection[J]. Chinese Journal of Pharmacovigilance, 2023, 20(11): 1293-1295.

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注射用培美曲塞二钠致双侧小腿罕见硬皮样皮肤1例分析

One case of scleroderma-like skin in bilateral calves induced by pemetrexed disodium for injection

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