中国药物警戒 ›› 2023, Vol. 20 ›› Issue (8): 935-938.
DOI: 10.19803/j.1672-8629.20230104

• 安全与合理用药 • 上一篇    下一篇

保妇康栓致异常子宫出血1例分析

常永卓1, 李季2, 张晓燕2, 周超凡3,*   

  1. 1北京丰台医院药剂科,北京100070;
    2北京丰台医院妇科,北京100070;
    3中国中医科学院中医基础理论研究所,北京100700
  • 收稿日期:2023-02-27 出版日期:2023-08-15 发布日期:2023-08-07
  • 通讯作者: *周超凡,男,主任医师,中药药理与药品不良反应。E-mail: zhouchaofan202299@126.com
  • 作者简介:常永卓,女,本科,副主任药师,临床药学。
  • 基金资助:
    北京丰台医院2022年院级科研项目（2022-15）

One case of abnormal uterine bleeding caused by Baofukang suppository

CHANG Yongzhuo1, LI Ji2, ZHANG Xiaoyan2, ZHOU Chaofan3,*   

  1. 1Department of Pharmacy, Beijing Fengtai Hospital, Beijing 100070, China;
    2Department of Gynaecology, Beijing Fengtai Hospital, Beijing 100070, China;
    3Institute of Basic Theory of Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China
  • Received:2023-02-27 Online:2023-08-15 Published:2023-08-07

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摘要： 目的 通过对病例追踪观察和文献分析,提出保妇康栓临床使用药学建议。方法 追踪1例慢性宫颈炎患者的治疗经过,对其用药后出现异常子宫出血分析发生原因,并检索相关文献进行分析。结果 患者因慢性宫颈炎、阴道炎使用保妇康栓后突然出现异常子宫出血,停用保妇康栓并口服氨甲环酸片后阴道出血干净,再次使用保妇康栓后又出现大量阴道出血并伴有子宫内膜样物质,月经周期异常,停用保妇康栓后,连续观察半年,未再次出现异常子宫出血,月经周期及月经量均恢复至用保妇康栓之前的状态。结论 建议临床应辨证与辨病相结合,对于没有严重瘀血凝滞,又素体脾胃虚弱、气血两虚的患者应慎用保妇康栓,以免造成崩漏及月经紊乱,对于有明显气滞血瘀且正气足脾胃健的患者可以选用,但不宜长期使用,以免损伤正气。

关键词: 保妇康栓, 莪术油, 异常子宫出血, 病例分析, 药品不良反应

Abstract: Objective To offer clinical pharmaceutical tips for the use of Baofukang suppository by retrospectively analyzing one case of abnormal uterine bleeding and reviewing literature. Methods The treatment process of one patient with chronic cervicitis was tracked, the causes of abnormal uterine bleeding after medication were analyzed, and related literature was retrieved. Results One patient with chronic cervicitis and vaginitis suddenly experienced abnormal uterine bleeding after using Baofukang suppository. After discontinuation of Baofukang suppository and medication with tranexamic acid tablets, vaginal bleeding stopped. When Baofukang suppository was used a second time, there was a large amount of vaginal bleeding accompanied by endometrial-like substances and abnormal menstrual cycle. After Baofukang suppository was discontinued, the patient experience no more abnormal uterine bleeding within six months. The menstrual cycle and volume returned to normal. Conclusion For patients without severe blood stasis but with spleen and stomach weakness or with qi and blood deficiency, Baofukang suppository should be used with caution to prevent breakouts and menstrual disorders. For patients with obvious qi stagnation and blood stasis but with full qi and healthy spleens and stomachs, Baofukang suppository can be used for a short period of time to avoid damaging the positive energy.

Key words: Baofukang suppository, zedoary turmeric oil, abnormal uterine bleeding, case analysis, adverse drug reactions

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