关键词: 狂犬病, 狂犬病毒, 狂犬病疫苗（Vero细胞）, 肾病综合征, 疫苗不良事件, 药品不良反应, 儿童

Abstract: Objective To study the adverse events of rabies vaccine and explore the adverse reactions among children with nephrotic syndrome. Methods By analyzing one case of nephrotic syndrome in children caused by rabies vaccine (Vero cells) (PVRV), the correlations with adverse drug reactions and the causal association of vaccine adverse events were discussed. Results Binocular eyelid edema appeared on the 4th day after the first dose, abdominal pain and vomiting on the 5th day, edema affected the face on the 8th day, and nephrotic syndrome was diagnosed on the 10th day. A third injection was not given, and the nephrotic syndrome was treated. After 3 days of medication with glucocorticoid, edema was mitigated and urine protein became negative. Conclusion A causal association between PVRV and nephrotic syndrome is possible and should be of concern to clinicians and pharmacists. Rabies vaccine (human diploid cells) is recommended for children with allergies.

Key words: rabies, rabies virus, rabies vaccine (Vero cells), nephrotic syndrome, adverse events following immunization, adverse drug reactions, child