中药防治耐药铜绿假单胞菌肺炎感染机制研究进展

doi:10.19803/j.1672-8629.20220328

摘要/Abstract

摘要： 目的综述中药防治铜绿假单胞菌肺炎感染机制的研究进展,为铜绿假单胞菌肺炎感染防治提供参考。方法查阅国内外文献,从中药调节细菌的耐药环节、调节群体感应系统、调节宿主微环境3方面进行综述。结果与抗生素直接靶向细菌相比,中药具有来源广泛、多途径、多靶点等作用特点,且具有副作用小、不易耐药、治疗成本低等优势。中药可以通过抑制灭活酶、调节细菌外排作用、调节群体感应系统、改善宿主屏障作用、调节免疫微环境等环节发挥作用。结论发掘中医药宝库,研究新型的抗耐药菌药物,具有十分重要的意义及良好的前景。

关键词: 中药, 耐药铜绿假单胞菌, 肺炎, 宿主微环境, 群体感应

Abstract: Objective To study the research progress in traditional Chinese medicines against multidrug-resistant Pseudomonas aeruginosa pneumonia and to provide reference for prevention and treatment of Pseudomonas aeruginosa pneumonia infections. Methods Domestic and foreign literature was consulted. The role of TCMs in regulation of bacterial drug resistance, the quorum sensing system, and host microenvironments was reviewed. Results Compared with antibiotics that directly target bacteria, traditional Chinese medicines were characterized by extensive sources, multiple components, multiple targets, and less resistance to drugs, which was of great value for treating multidrug-resistant Pseudomonas aeruginosa pneumonia. Traditional Chinese medicines can play a role in treating anti-bacterial pneumonia by inhibiting the expressions of inactivated enzymes, inhibiting bacterial efflux, regulating the quorum sensing system, improving the host innate immune barrier, and regulating the immune microenvironment. Conclusion It is of great significance to explore the treasure house of TCMs and develop new drugs that are effective against multidrug-resistant Pseudomonas aeruginosa pneumonia in the future.

Key words: traditional Chinese medicine, multidrug-resistant Pseudomonas aeruginosa, pneumonia, host microenvironment, quorum sensing system

中图分类号:

R978

徐英莉, 庞博, 曹姗, 陈梦苹, 孙静, 赵荣华, 张敬升, 周利润, 王雅欣, 崔晓兰. 中药防治耐药铜绿假单胞菌肺炎感染机制研究进展[J]. 中国药物警戒, 2023, 20(1): 57-60.

XU Yingli, PANG Bo, CAO Shan, CHEN Mengping, SUN Jing, ZHAO Ronghua, ZHANG Jingsheng, ZHOU Lirun, WANG Yaxin, CUI Xiaolan. Research progress in traditional Chinese medicines against multidrug-resistant Pseudomonas aeruginosa pneumonia[J]. Chinese Journal of Pharmacovigilance, 2023, 20(1): 57-60.

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