中国药物警戒 ›› 2022, Vol. 19 ›› Issue (3): 302-305.
DOI: 10.19803/j.1672-8629.2022.03.15

• 安全与合理用药 • 上一篇    下一篇

非瓣膜性心房颤动老年患者用药现状及影响因素分析

柴晓利1, 张臣1, 丰庆春1, 刘欢2   

  1. 1湖南省脑科医院心血管内科,湖南 长沙 410015;
    2湖南中医药大学,湖南 长沙 410015
  • 收稿日期:2020-05-22 出版日期:2022-03-15 发布日期:2022-03-16
  • 作者简介:柴晓利,女,硕士,主任医师,临床心血管疾病。
  • 基金资助:
    湖南省卫生和计划生育委员会项目（B2015-104）

Current medications and influencing factors for senile patients with NVAF

CHAI Xiaoli1, ZHANG Chen1, FENG Qingchun1, LIU Huan2   

  1. 1Department of Cardiology, Hunan Brain Hospital, Changsha Hunan 410015,China;
    2Hunan University of Traditional Chinese Medicine, Changsha Hunan 410015, China
  • Received:2020-05-22 Online:2022-03-15 Published:2022-03-16

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摘要： 目的 探讨非瓣膜性心房颤动（non-valvular atrial fibrillation, NVAF）老年患者用药现状及对抗凝治疗的影响。方法 选取2015年3月1日至2019年3月31日在我市5家三甲医院心血管内科住院NVAF老年患者482例作为研究对象,采用自制问卷调查人口统计学资料,随访记录患者连续使用1个月以上的药物;比较2组间人口统计学资料差异,评价抗栓及多重用药（≥5种用药）治疗现状,采用Logistic分析多重用药的影响因素。结果 482例患者中,250 例（51.87%）治疗合理,58例（12.05%）治疗过度,37例（7.68%）治疗不足,137例（28.42%）未治疗。482例患者中多重用药234例,非多重用药组248例。Logistic因素回归分析显示,文化程度、医保类型、高血压、糖尿病、冠心病及心力衰竭为多重用药的独立危险因素（P<0.05）。结论 老年NVAF患者普遍存在多重用药情况;需提高抗凝治疗的比例。

关键词: 老年患病, 非瓣膜性心房颤动, 多重用药, 抗凝治疗

Abstract: Objective To investigate current medications for elderly patients with non-valvular atrial fibrillation (NVAF) and the effect on anticoagulant therapies. Methods A total of 482 elderly patients with NVAF hospitalized in cardiovascular departments of five big hospitals in Changsha between March 2015 and March 2019 were selected as the subjects. A self-designed questionnaire was used to investigate the demographic data that was compared between the two groups. The usage of antithrombotic therapies and multiple drugs (≥5 drugs) was evaluated, and the influencing factors of multiple drugs were analyzed by logistic regression analysis. Results Among the 482 patients, 250 (51.87%) were properly treated, 58 (12.05%) were over-treated, 37 (7.68%) were undertreated, and 137 (28.42%) were left untreated. Logistic regression analysis showed that levels of education, type of medical insurance, hypertension, diabetes, coronary heart disease and heart failure were independent risk factors for multiple drug use (P<0.05). Conclusion Multiple medication is common in elderly NVAF patients, and the proportion of anticoagulant therapies needs to be improved.

Key words: advanced age, non-valvular atrial fibrillation, multiple drug use, anticoagulation

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