中国药物警戒 ›› 2022, Vol. 19 ›› Issue (1): 72-73.
DOI: 10.19803/j.1672-8629.2022.01.15

• 基础与临床研究 • 上一篇    下一篇

化疗联合安罗替尼在晚期胰腺癌中的观察分析

徐宝余1,2, 沈华3, 李歆1,*, 韩峰1#   

  1. 1南京医科大学药学院,江苏 南京 211166;
    2南京医科大学基础医学院人体解剖学系,江苏 南京 211166;
    3南京医科大学附属逸夫医院,江苏 南京 211166
  • 收稿日期:2021-04-30 出版日期:2022-01-15 发布日期:2022-01-20
  • 通讯作者: *李歆,男,博士,教授·博导,临床药学与政策。E-mail：xinli@njmu.edu.cn。#为共同通信作者。
  • 作者简介:徐宝余,男,硕士,临床药学。
  • 基金资助:
    国家自然科学基金资助项目（72074123, 716731471）; 江苏省政策引导类计划（软科学研究）（BR2020043）; 吴阶平医学基金会临床科研专项资助基金（320.6750.2020-10-74）

Efficacy of chemotherapy combined with anlotinib against advanced pancreatic cancer

XU Baoyu1,2, SHEN Hua3, LI Xin1,*, HAN Feng1,*   

  1. 1School of Pharmacy, Nanjing Medical University, Nanjing Jiangsu 211166, China;
    2Depar-tment of Human Anatomy, School of Basic Medical Sciences, Nanjing Medical University, Nanjing Jiangsu 211166, China;
    3Sir Run Run Hospital, Nanjing Medical University, Nanjing Jingsu 211166, China
  • Received:2021-04-30 Online:2022-01-15 Published:2022-01-20

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摘要： 目的 研究化疗联合抗血管生成药物在晚期胰腺癌中的疗效。方法 回顾性分析2019年10月31日至2021年2月28日南京医科大学附属逸夫医院及海安市人民医院肿瘤科治疗的60例晚期胰腺癌患者,按照患者的不同治疗方案分为试验组和对照组,每组各 30 例。对照组给予单药吉西他滨治疗,试验组给予白蛋白结合型紫杉醇与吉西他滨作为主化疗联合安罗替尼治疗。比较2组患者的生存情况及主要不良反应情况。结果 化疗联合安罗替尼治疗能够延长晚期胰腺癌患者的生存时间。结论 化疗联合安罗替尼可提高晚期胰腺癌的疗效,为临床治疗晚期胰腺病提供参考。

关键词: 胰腺癌, 吉西他滨, 白蛋白结合型紫杉醇, 安罗替尼

Abstract: Objective To investigate the efficacy of chemotherapy combined with anlotinib in treating advanced pancreatic cancer. Methods The clinical data on 60 patients with advanced pancreatic cancer was retrospectively analyzed who had been treated at Yifu Hospital and Hai'an People's Hospital between October 31, 2019 and February 28, 2021. The patients were divided into a control group and a test group using the random number table method, with 30 in each group. Patients in the control group were treated with single-agent gemcitabine while those in the experimental group were treated with albumin-bound paclitaxel and gemcitabine as the main chemotherapy combined with anlotinib. The overall survival and incidence of adverse reactions were observed. Results Chemotherapy combined with anlotinib prolonged the survival of patients with advanced pancreatic cancer. Conclusion Chemotherapy combined with anlotinib can improve the therapeutic effect against advanced pancreatic cancer.

Key words: pancreatic cancer, gemcitabiner, albumin-bound paclitaxel, anlotinib

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