补充锌制剂在新型冠状病毒肺炎治疗中的辅助作用及应用前景

doi:10.19803/j.1672-8629.2021.10.04

摘要/Abstract

摘要： 目的探讨补充锌制剂在新型冠状病毒肺炎（COVID-19）治疗中的作用及前景。方法综述关于锌离子抗病毒免疫作用的当代研究以及补充锌制剂对COVID-19患者潜在的辅助治疗作用,总结应用锌制剂治疗COVID-19相关临床研究的初步结果。结果锌制剂具有改善免疫,有一定减少感染和炎症的作用,锌可抑制多种病毒核糖核酸（RNA）复制过程,从而有一定的抗病毒作用。锌状态是影响抗新型冠状病毒免疫的一个关键因素。结论建议增加锌制剂辅助治疗新型COVID-19。

关键词: 锌制剂, 新型冠状病毒, 新型冠状病毒肺炎

Abstract: Objective To explore the adjunctive role and prospects of zinc supplementation in the treatment of COVID-19. Methods Current research on the role of zinc in antiviral immunity and the potential role of zinc in combating COVID-19 was reviewed, and findings of the ongoing clinical trials related to COVID-19 were summarized. Results Zinc supplementation could improve immunity and alleviate infection and inflammation. Zinc could inhibit the replication process of a variety of viral RNA, so it had some antiviral effect. Zinc status was a key factor that affected the immune response to COVID-19. Conclusion It is recommended that zinc supplementation be used as an adjunctive treatment for COVID-19.

Key words: zinc, SARS-CoV-2, COVID-19

中图分类号:

R978.7

田地, 穆雪纯, 陈志海. 补充锌制剂在新型冠状病毒肺炎治疗中的辅助作用及应用前景[J]. 中国药物警戒, 2021, 18(10): 915-919.

TIAN Di, MU Xuechun, CHEN Zhihai. Adjunctive Role and Prospects of Zinc Supplementation for Treatment of COVID-19[J]. Chinese Journal of Pharmacovigilance, 2021, 18(10): 915-919.

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