中国药物警戒 ›› 2021, Vol. 18 ›› Issue (8): 710-714.
DOI: 10.19803/j.1672-8629.2021.08.03

• 基于真实世界的中成药联合用药方案研究专栏 • 上一篇    下一篇

脉络舒通丸治疗骨外科疾病真实世界用药特征分析

成冯镜茗1, 王连心1#, 谢雁鸣1,*, 庄严2   

  1. 1中国中医科学院中医临床基础医学研究所,北京 100700;
    2中国人民解放军海军总医院,北京 100048
  • 收稿日期:2021-02-18 出版日期:2021-08-15 发布日期:2021-08-17
  • 通讯作者: *谢雁鸣,女,首席研究员·博导,中医临床评价。E-mail: ktzu2018@163.com #为共同通信作者。
  • 作者简介:成冯镜茗,女,硕士,中西医结合临床（中成药上市后循证评价）。
  • 基金资助:
    国家重点研发计划（2018YFC1707400）; 全国中医药创新骨干人才培养项目（Z0687）; 国家自然科学基金资助项目（81973982）

Analysis of Drug Characteristics of Mailuoshutong Pill Treating Patients with Orthopedic and Surgical Disease in Real World

CHENG Fengjingming1, WANG Lianxin1#, XIE Yanming1,*, ZHUANG Yan2   

  1. 1Institute of Clinical and Basic Medicine of Traditional Chinese Medicine, Chinese Academy of Chinese Medical Sciences, Beijing 100700, China;
    2Center of Computer Management, Navy General Hospital of PLA, Beijing 100048, China
  • Received:2021-02-18 Online:2021-08-15 Published:2021-08-17

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摘要： 目的 了解脉络舒通丸治疗骨外科疾病的临床联合用药特征,挖掘其规律。方法 提取来自全国14家大型三甲医院信息系统中2006~2016年使用过脉络舒通丸至少1次的骨外科疾病患者信息,共3 173例,描述临床联合用药特征。结果 使用脉络舒通丸的骨外科疾病患者平均年龄为（42.74±16.33）岁,男女比例为2.54∶1,18~45岁的患者居多（46.14％）。联合用药中,脉络舒通丸合并1种中药用药频数最高的为红花注射液（9.77%）;合并1种西药用药最常为苯巴比妥（6.4%）。关联规则显示联合1种中药合并1种西药常为仙灵骨葆胶囊和头孢唑林（9.39%）;联合1种中药合并2种西药多为仙灵骨葆胶囊、头孢唑林、苯巴比妥（8.54%）;联合1种中药合并3种西药常为仙灵骨葆胶囊、头孢唑林、苯巴比妥、肌苷（4.92%）。结论 本研究探索了真实世界中脉络舒通丸治疗骨外科疾病的联合用药特征,脉络舒通丸常合并活血化瘀类、补肾壮骨类、健脾通便类中药联合应用,常与镇静止痛类、抗菌类、抗炎症类、抑酸护胃类西药联合应用。为其在骨外科疾病的临床联合用药提供参考依据,但仍需在证据级别更高的临床研究中作进一步的验证。

关键词: 脉络舒通丸, 骨外科疾病, 真实世界, 关联规则

Abstract: Objective To find out about the clinical characteristics of combined use of Mailuoshutong pills in the treatment of orthopedic and surgical diseases. Methods Information about 3173 patients with orthopedic and surgical diseases who used Mailuoshutong pills at least once in the information system of 14 large tertiary hospitals in China between 2006 and 2016 was retrieved. The clinical characteristics of drug combination were described. Results The average age of these patients was (42.74±16.33) years old, and the ratio of males to females was 2.54∶1. The majority of patients were 18-45 years old (46.14%). Among the combined drugs, Honghua injection (9.77%) was most likely to be used with Mailuoshutong pills. Phenobarbital (6.4%) was the most common drug used in combination with one type of western medicine. Association rules showed the combination of one type of traditional Chinese medicine and one type of western medicine was usually between Xianling Gubao capsules and cefazolin (9.39%). The combination of one type of traditional Chinese medicine and two types of western medicines was usually between Xianling Gubao capsules and cefazolin and phenobarbital (8.54%). The combination of one type of traditional Chinese medicine and three types of western medicines normally involved Xianling Gubao capsules, cefazolin, phenobarbital and inosine (4.92%). Conclusion Mailuoshutong pills are often combined with such traditional Chinese medicines that can invigorate blood circulation and remove blood stasis, tonify the kidney and strengthen bones, invigorate the spleen and facilitate defecation. These pills are also often combined with western medicines that are sedative, painkilling, antibacterial, anti-inflammatory, acid suppressive and stomach-protecting. This study has provided data for clinical drug combination against orthopedic and surgical diseases. Further verification is needed to carry out clinical studies at a higher level of evidence.

Key words: Mailuoshutong pills, orthopedic and surgical disease, the real world, association rules

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