剖宫产瘢痕部位妊娠使用甲氨蝶呤致严重口腔溃疡及Ⅲ度骨髓抑制1例分析

doi:10.19803/j.1672-8629.2021.01.18

中国药物警戒 ›› 2021, Vol. 18 ›› Issue (1): 87-89.
DOI: 10.19803/j.1672-8629.2021.01.18

剖宫产瘢痕部位妊娠使用甲氨蝶呤致严重口腔溃疡及Ⅲ度骨髓抑制1例分析

何寿芸¹, 吴颖其^2,*

¹芜湖市第二人民医院,安徽芜湖 241000;
²中国科学技术大学附属第一医院安徽省立医院,安徽合肥 230000

收稿日期:2019-11-03 修回日期:2021-01-18 出版日期:2021-01-15 发布日期:2021-01-18
通讯作者: ^*吴颖其,女,硕士,主管药师,妇产科临床药学。E-mail:wyq0551@126.com
作者简介:何寿芸,女,硕士,主管药师,临床药学。
基金资助:
省级质量工程项目(2018jyxm0749)

One Case of Cesarean Scar Pregnancy with Severe Aphthous Ulcer and Ⅲ Degree Myelosuppression Induced by Methotrexate

HE Shouyun¹, WU Yingqi^2,*

¹The Second People's Hospital of Wuhu,Wuhu Anhui 241000,China;
²The First Affiliated Hospital of USTC Anhui Provincial Hospital,Hefei Anhui 230000,China

Received:2019-11-03 Revised:2021-01-18 Online:2021-01-15 Published:2021-01-18

摘要/Abstract

摘要： 目的为临床更加规范使用甲氨蝶呤以减少药品不良反应(ADR)发生及处置提供参考。方法临床药师通过参与1例因剖宫产瘢痕部位妊娠使用甲氨蝶呤后导致严重口腔溃疡和Ⅲ度骨髓抑制患者的治疗过程,从ADR发生原因、防治方法及药学监护方面进行分析。结果通过对患者进行MTHFR基因型检测以及提前做好防治措施,可避免或减轻甲氨蝶呤ADR。结论临床药师参与患者治疗过程,可对患者进行药学监护和用药教育,提高临床治疗水平,并为患者提供更安全、有效、经济、合理的药学服务。

关键词: 甲氨蝶呤, 口腔溃疡, 骨髓抑制, 临床药师, 药学监护

Abstract: Objective To provide reference for more rational clinical use of methotrexate in order to reduce adverse drug reaction(ADR) and treatment methods after ADR.Methods Clinical pharmacists participated in a case for cesarean scar pregnancy with severe aphthous ulcer and III degree myelosuppression caused by methotrexate chemotherapy ,analyzed the ADR causes,prevention and cure,and pharmaceutical care.Results The ADR of methotrexate can be avoided or alleviated through the detection of MTHFR genotype in patients and preventive measures in advance.Conclusion The participation of clinical pharmacists in the treatment of patients can provide pharmaceutical care and medication education for patients,improve the level of clinical treatment,and provide more safe,effective,economical and reasonable pharmaceutical care for patients.

Key words: methotrexate, aphthous ulcer, myelosuppression, clinical pharmacist, pharmaceutical care

中图分类号:

R969.3

何寿芸, 吴颖其. 剖宫产瘢痕部位妊娠使用甲氨蝶呤致严重口腔溃疡及Ⅲ度骨髓抑制1例分析[J]. 中国药物警戒, 2021, 18(1): 87-89.

HE Shouyun, WU Yingqi. One Case of Cesarean Scar Pregnancy with Severe Aphthous Ulcer and Ⅲ Degree Myelosuppression Induced by Methotrexate[J]. Chinese Journal of Pharmacovigilance, 2021, 18(1): 87-89.

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剖宫产瘢痕部位妊娠使用甲氨蝶呤致严重口腔溃疡及Ⅲ度骨髓抑制1例分析

One Case of Cesarean Scar Pregnancy with Severe Aphthous Ulcer and Ⅲ Degree Myelosuppression Induced by Methotrexate

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