中国药物警戒 ›› 2020, Vol. 17 ›› Issue (12): 904-906.
DOI: 10.19803/j.1672-8629.2020.12.12

• 安全与合理用药 • 上一篇    下一篇

157例碘普罗胺注射液药品不良反应报告分析

程小平1, 朱雅健2, 刘学良3   

  1. 1青海省药品不良反应监测中心,青海 西宁 810007;
    2青海省药品监督管理局,青海 西宁 810007;
    3青海省食品药品监督管理局食品药品审评中心,青海 西宁 810007
  • 收稿日期:2020-05-06 修回日期:2020-12-07 出版日期:2020-12-15 发布日期:2020-12-07
  • 作者简介:程小平,男,副主任药师,药品不良反应监测与评价。
  • 基金资助:
    青海省科技计划项目(2020-ZJ-747)

157 Cases of Adverse Drug Reactions Induced by Iopromide Injection

CHENG Xiaoping1, ZHU yajian2, LIU Xueliang3   

  1. 1Center for ADR Monitoring of Qinghai,Xining Qinghai 810007,China;
    2Qinghai Provincial Drug Administration,Xining Qinghai 810007,China;
    3Qinghai Food and Drug Administration Technical Evaluation Center,Xining Qinghai 810007,China
  • Received:2020-05-06 Revised:2020-12-07 Online:2020-12-15 Published:2020-12-07

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摘要： 目的 探讨分析碘普罗胺注射液药品不良反应(ADR)临床特点和发生规律,为减低临床用药风险提供参考。方法 采用回顾性研究方法,对国家药品不良反应监测系统青海省数据库中2009~2019年收集的157例碘普罗胺注射液ADR报告进行了统计分析。结果 碘普罗胺注射液所致ADR男性少于女性,不良反应发生时间在30 min内占68.16%,临床表现以皮肤及其附件损害最多,过敏性休克最严重。结论 为确保用药安全,临床应严格遵守药品说明书,用药前后需密切关注ADR,做到早识别、增加早干预,减少碘普罗胺注射液ADR的发生。

关键词: 碘普罗胺注射液, 药品不良反应, 分析

Abstract: Objective To explore the clinical characteristics and regularity of adverse reactions (ADR) caused by iopromide injection so as to provide reference for reducing the risk of clinical medication.Methods The ADR reports of 157 cases of iopromide injection collected between 2009 and 2019 from the provincial database of the national adverse drug reaction monitoring system were statistically analyzed using the retrospective research method.Results ADRs caused by iopromide injection were more common among females than among males, and 68.16% of the ADRS occurred within 30 minutes of medication. The dominating clinical manifestations were the damage to the skin and its accessories, and anaphylactic shock was the most serious consequence.Conclusion In order to ensure the safety of drug use, drug instructions should be strictly observed clinically. Attention should be paid to the serious adverse reactions before and after drug use so as to identify and prevent ARDs as soon as possible and reduce the incidence of ADRs related to this injection.

Key words: lopromide injection, adverse drug reactions, rational drug application

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