三拗片致水潴留及神经精神症状1例分析

doi:10.19803/j.1672-8629.2020.10.18

中国药物警戒 ›› 2020, Vol. 17 ›› Issue (10): 732-734.
DOI: 10.19803/j.1672-8629.2020.10.18

三拗片致水潴留及神经精神症状1例分析

曹建英, 王潇, 宋玉环, 冯占芹, 曲秀君^*

潍坊市妇幼保健院药剂科,山东潍坊 261011

收稿日期:2020-10-14 修回日期:2020-10-14 出版日期:2020-10-15 发布日期:2020-10-13
通讯作者: ^*曲秀君,女,硕士,副主任药师,药事管理。E-mail：18506366256@163.com
作者简介:曹建英,女,本科,副主任药师,临床药学及药品不良反应监测。

Water Retention and Neuropsychiatric Symptoms Induced by SAN AO PIAN

CAO Jianying, WANG Xiao, SONG Yuhuan, FENG Zhanqin, QU Xiujun^*

Department of Pharmacy, Weifang Maternal and Child Health Hospital, Weifang Shandong 261011, China

Received:2020-10-14 Revised:2020-10-14 Online:2020-10-15 Published:2020-10-13

摘要/Abstract

摘要： 目的分析三拗片致水潴留及神经精神症状的安全性风险,为临床合理用药提供参考。方法报道1例三拗片引起的药品不良反应,分析其发生原因。检索文献数据库,对2000年1月至2019年7月有关麻黄及含麻黄药品引起的药品不良反应进行挖掘整理。结果三拗片所致药品不良反应与其麻黄组分及用药适应证不适宜相关。麻黄的主要成分麻黄碱,可致中枢神经和交感神经兴奋,还可导致膀胱括约肌收缩和逼尿肌松弛,引起神经精神症状及排尿困难。结论应重视三拗片药品不良反应监测,麻黄过敏者尤应注意,临床亦需辨证施治,促进安全合理用药。

关键词: 三拗片, 麻黄, 神经精神症状, 水潴留

Abstract: Objective To analyze the safety risk of water retention and neuropsychiatric symptoms induced by SAN AO PIAN (tablets). Methods The risk signals of one case of adverse reactions induced by SAN AO PIAN were reported while the causes were analyzed. Related databases were searched to mine ADR data about ephedra and ephedra-containing drugs that was published between January 2000 and July 2019. Results The adverse reactions induced by SAN AO PIAN were related to ephedra it contained and contraindications. Ephedrine, the main component of ephedra, can excite the central and sympathetic nerves, cause bladder sphincter contraction and detrusor relaxation, and induce neuropsychiatric symptoms and dysuria. Conclusion Clinicians should be alert to the adverse drug reactions caused by SAN AO PIAN, especially in patients with ephedra allergies. Clinical treatment should be provided in conjunction with syndrome differentiation to promote safe and rational use of drugs.

Key words: SAN AO PIAN, ephedra, neuropsychiatric symptoms, water retention

中图分类号:

R994.11

曹建英, 王潇, 宋玉环, 冯占芹, 曲秀君. 三拗片致水潴留及神经精神症状1例分析[J]. 中国药物警戒, 2020, 17(10): 732-734.

CAO Jianying, WANG Xiao, SONG Yuhuan, FENG Zhanqin, QU Xiujun. Water Retention and Neuropsychiatric Symptoms Induced by SAN AO PIAN[J]. Chinese Journal of Pharmacovigilance, 2020, 17(10): 732-734.

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三拗片致水潴留及神经精神症状1例分析

Water Retention and Neuropsychiatric Symptoms Induced by SAN AO PIAN

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