中国药物警戒 ›› 2020, Vol. 17 ›› Issue (6): 381-383.
DOI: 10.19803/j.1672-8629.2020.06.14

• 安全与合理用药 • 上一篇    下一篇

盐酸曲马多注射液致哮喘1例分析

王康韬1, 陈江辉2, 田影2, 叶春艳2, 裴海平1*   

  1. 1 中南大学湘雅医院胃肠外科,湖南 长沙 410008;
    2 中南大学湘雅医院麻醉科,湖南 长沙 410008
  • 收稿日期:2019-03-11 修回日期:2020-06-22 出版日期:2020-06-15 发布日期:2020-06-01
  • 通讯作者: *裴海平,男,博士,教授·博导,胃肠道肿瘤发生发展及抗肿瘤药物机制。E-mail：peihaiping1966@163.com
  • 作者简介:王康韬,男,在读硕士,胃肠外科临床及基础研究。
  • 基金资助:
    中南大学2018年研究生创新项目（2018zzts910）

Asthma Induced by Tramadol Hydrochloride Injection

WANG Kangtao1, CHEN Jianghui2, TIAN Ying2, YE Chunyan2, PEI Haiping1*   

  1. 1 Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Changsha Hunan 410008, China;
    2 Department of Anesthesiology, Xiangya Hospital, South China University, Changsha Hunan 410008, China
  • Received:2019-03-11 Revised:2020-06-22 Online:2020-06-15 Published:2020-06-01

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摘要： 目的 对盐酸曲马多注射液致哮喘的分析,为临床安全用药提供参考。方法 报道中南大学湘雅医院麻醉科2019年2月出现的1例注射盐酸曲马多后导致哮喘过敏反应。对国内外数据库此类报道进行检索并回顾分析。结果 本例手术麻醉后寒战患者2次肌内注射曲马多注射液后均出现哮喘症状,心率增高,血压降低,经抗过敏和对症紧急处理后症状缓解,心率血压恢复。数据库检索最终纳入中外7篇论文进行分析。结论 使用曲马多进行治疗时,需密切关注患者的生命体征,一旦出现呼吸急促,心动过速的不良反应时,应及时停药,给予呼吸支持、支气管扩张剂、抗过敏药物治疗。

关键词: 盐酸曲马多, 哮喘, 不良反应, 过敏反应

Abstract: ：Objective To analyze rare allergic reactions caused by tramadol hydrochloride injection. Methods One case of allergic reactions (asthma) after tramadol hydrochloride injection in our Department of Anesthesiology in February 2019 was reported. Related literature was searched for retrospective analysis. Results A patient with chills after operation and anesthesia was twice treated with tramadol injection, resulting in asthma, faster heart rate and lower blood pressure. After emergency treatment, the patient returned to normal. Seven papers from databases were included and analyzed. Conclusion Tramadol should be used with caution. In case of such adverse reactions as shortness of breath or tachycardia, tramadol injection should be stopped immediately, while respiratory support should be provided and bronchodilators and antiallergic drugs should be given.

Key words: tramadol hydrochloride, asthma, adverse reactions, anaphylactic reaction

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