中国药物警戒 ›› 2020, Vol. 17 ›› Issue (1): 23-25.
DOI: 10.19803/j.1672-8629.2020.01.05

• 临床研究 • 上一篇    下一篇

头孢哌酮钠舒巴坦钠对使用阿司匹林和氯吡格雷脑血管病患者凝血功能的影响

梁河1, 蒙光义1, 钟丽球1, 周丽娟1, 梁春宏1, 庞家容2   

  1. 1玉林市第一人民医院药学部,广西 玉林 537000;
    2玉林市第一人民医院神经内科,广西 玉林 537000
  • 收稿日期:2019-04-15 修回日期:2020-01-15 出版日期:2020-01-15 发布日期:2020-01-15
  • 作者简介:梁河,女,本科,副主任药师,临床药学。
  • 基金资助:
    广西玉林市科学研究与技术开发计划项目（玉市科20171606）:头孢哌酮钠舒巴坦钠对使用阿司匹林和氯吡格雷的脑血管病患者凝血功能的影响

Effect of Cefoperazone Sodium and Sulbactam Sodium on Coagulation Function of Cerebrovascular Disease Patients Using Aspirin and Clopidogrel

LIANG He1, MENG Guangyi1, ZHONG Liqiu1, ZHOU Lijuan1, LIANG Chunhong1, PANG Jiarong2   

  1. 1Department of Pharmacy, First People's Hospital of Yulin, Yulin Guangxi 537000, China;
    2Department of Neurology, First People's Hospital of Yulin, Yulin Guangxi 537000, China
  • Received:2019-04-15 Revised:2020-01-15 Online:2020-01-15 Published:2020-01-15

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摘要： 目的 探讨头孢哌酮钠舒巴坦钠对使用阿司匹林和氯吡格雷的脑血管病患者凝血功能的影响。方法 回顾性收集我院神经内科收治的60例缺血性脑血管病合并肺炎患者为研究对象,根据不同的抗感染治疗药物分为对照组（哌拉西林钠他唑巴坦钠治疗）和观察组（头孢哌酮钠舒巴坦钠治疗）,每组30例,观察和评价头孢哌酮钠舒巴坦钠对使用阿司匹林和氯吡格雷的脑血管病患者凝血功能的影响,包括活化部分凝血酶原时间（APTT）、凝血酶原时间（PT）、凝血酶时间（TT）、血小板计数（PLT）。结果 与治疗前比较,治疗后两组患者APTT、PT升高,差异有统计学意义（P<0.05）;与治疗后对照组比较,观察组APTT、PT升高,差异有统计学意义（P<0.01）;治疗前后TT和PLT组间、组内比较均无统计学意义（P>0.05）。结论 头孢哌酮钠舒巴坦钠在阿司匹林和氯吡格雷的基础上对脑血管病患者APTT、PT产生显著影响,需警惕联合用药的出血风险。

关键词: 头孢哌酮钠舒巴坦钠, 凝血功能, 活化部分凝血酶原时间, 凝血酶原时间

Abstract: Objective To investigate the effect of cefoperazone sodium and sulbactam sodium on coagulation function of cerebrovascular patients treated with aspirin and clopidogrel. Methods Sixty patients with ischemic cerebrovascular disease and pneumonia treated in the Department of Neurology were selected as the subjects, who were divided into the control group (treated with piperacillin sodium and tazobactam sodium, n=30) and observation group (treated with cefoperazone sodium and sulbactam sodium, n=30) based on different anti-infective regimens. The activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT) and platelet count (PLT) were detected to evaluate the effect of cefoperazone sodium and sulbactam sodium on coagulation function. Results The APTT and PT increased significantly (P <0.05) in the two groups after treatment, especially in the observation group. The APTT and PT in the observation group after treatment were longer than in the control group (P <0.01). There was no obvious change in TT or PLT after treatment (P >0.05). Moreover, there was no statistically significant difference in TT or PLT between the two groups. Conclusion Cefoperazone sodium and sulbactam sodium can affect the coagulation function of patients treated with aspirin and clopidogrel, especially the change of APTT and PT. So doctors have to be alert to the risk of bleeding in combined medication.

Key words: cefoperazone sodium and sulbactam sodium, coagulation function, APTT, PT

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