国内外鼠疫抗菌治疗方案辨析及前瞻

doi:10.19803/j.1672-8629.2020.01.01

摘要/Abstract

摘要： 鼠疫是一种发病急、传播快、传染性极强且病死率极高的自然疫源性传染病。世界范围内,鼠疫疫源地多,存在不同生物型及生态型菌株。近年鼠疫疫情卷土重来,在非洲等多地出现抬头,我国、美国等国家鼠疫疫情也未曾间断。目前国内外鼠疫抗菌治疗方案存在差异,链霉素使用剂量争议最大。为指导医务人员根据不同的鼠疫疫源地、生物型、临床类型制定个体化的抗菌治疗方案,本文对有关鼠疫抗菌治疗国内外指南、方案和文献进行比较、分析,探讨鼠疫抗菌治疗策略,为未来治疗及研究提供参考。

关键词: 鼠疫, 鼠疫菌, 抗菌治疗, 指南, 链霉素, 联合用药

Abstract: Plague is a kind of natural epidemic infectious disease with rapid transmissions, acute onsets, strong infectivity and high fatality rates. There are many plague natural foci in the world, and various biotypes and ecotypes of Yersinia pestis strains as well.In recent years, plague has been reemerging, and there has been a rising trend in many places especially in Africa. China, the United States and other countries are reporting sporadic plague cases. At present, among the differences between domestic and foreign guidelines for the antibacterial treatment of plague, the dosage of streptomycin is the most controversial one. In order to guide medical staff to formulate individualized antibacterial treatment strategy when dealing with different plague foci, biotypes strains and clinical types, this paper compares and analyzes domestic and foreign guidelines and literatures about the antibacterial treatment of plague, and discusses the antibacterial strategies of plague, so as to provide references for future treatments and related researches.

Key words: plague, yersina pestis, antibacterial treatment, guidelines, streptomycin, drug combination.

中图分类号:

R978

陈冲, 葛子若, 王琳, 陈志海. 国内外鼠疫抗菌治疗方案辨析及前瞻[J]. 中国药物警戒, 2020, 17(1): 1-5.

CHEN Chong, GE Ziruo, WANG Lin, CHEN Zhihai. Analysis and Prospect of Domestic and Foreign Plague Antibacterial Treatment Plan[J]. Chinese Journal of Pharmacovigilance, 2020, 17(1): 1-5.

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