常用药物肝损伤发生机制研究进展

doi:10.19803/j.1672-8629.2019.12.09

摘要/Abstract

摘要： 目的总结归纳药物性肝损伤机制的最新研究进展,为深入了解药物性肝损伤机制提供参考。方法通过文献检索和归纳,总结了四类易致肝损伤的药物：非甾体抗炎药、抗生素和抗真菌药物、神经系统药物、中草药的肝损伤作用机制。结果该类药物肝损伤机制涉及线粒体功能障碍和氧化应激、患者的基因多态性、活性代谢物、免疫反应等。结论应该进一步加强药物性肝损伤机制的研究和总结,以最大限度地规避药物性肝损伤的发生,指导相关药物的合理应用。

关键词: 药物性肝损伤, 作用机制, 肝毒性

Abstract: Objective To summarize the latest research progress related to drug-induced liver injury in order to achieve a better understanding of the related mechanisms. Methods Through literature search and summary, the mechanisms of drug actions which are likely to induce liver injury were summarized, involving non-steroidal anti-inflammatory drugs, antibiotics and antifungal drugs, nervous system drugs, and Chinese herbal medicines. Results The mechanisms of liver injury by these drugs are related to mitochondrial dysfunction and oxidative stress, gene polymorphism, active metabolites and immune response. Conclusion More studies on the mechanisms of drug-induced liver injury are required to reduce the occurrence of drug-induced liver injury and guide the rational use of related drugs.

Key words: drug-induced liver injury, mechanism, hepatotoxicity

中图分类号:

R994.11

李红颖, 杨翠平, 靳洪涛. 常用药物肝损伤发生机制研究进展[J]. 中国药物警戒, 2019, 16(12): 750-756.

LI Hongying, YANG Cuiping, JIN Hongtao. Recent Research Progress in Mechanism of Liver Injury Induced by Common Drugs[J]. Chinese Journal of Pharmacovigilance, 2019, 16(12): 750-756.

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